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Related post: SECTION Epidemiology Section INSTITUTE AND LOCATION NIAID, NTH, Bethesda, MP 20892 TOTAL MAN-YEARS: 1.9 PROFESSIONAL: 0.6 1.3 CHECK APPROPRIATE BOX(ES) Q (a) Human subjects D (b) Human tissues □ (c) Neither Q (a1) Minors Ex (a2) Interviews SUMMARY OF WORK (Use standard Cheap Tegopen unreduced type. Do not exceed the space provided.) Previous field trials of the rhesus rotavirus (RRV) vaccine in young infants in Venezuela, Rochester, and Arizona have indicated that serotype specific immunity is necessary for protection against rotavirus diarrhea. This goal could be achieved by incorporating into a candidate vaccine (i) a strain which is highly cross-reactive with a wide range of wild type human rotaviruses, or (ii) strains that collectively represent the VP7 serotype repertoire of epidemiologically important rotaviruses. The second approach was investigated in phase 1 studies designed to evaluate the antigenicity and reactogenicity of human rotavirus-RRV reassortants with the VP7 specificity of human Buy Tegopen serotypes 1 (D x RRV), or 2 (DS1 x RRV). These studies were carried out in Venezuela and Peru. The 2 reassortant vaccines were compared with the candidate RRV vaccine. A quadrivalent vaccine composed of RRV, D x RRV, DS1 x RRV, and a serotype 4 x RRV reassortant (ST3 x RRV) has also been tested in Venezuela. In addition, we have tested a new vaccine candidate developed in LID, the M37 strain, originally isolated from an asymptomatic newborn infant. U-pT PHS 6040 (Rev. 1/84) cpo9I4-«i« DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER Z01 AI 00451-04 LID PERIOD COVERED October 1, 1989 to September 30, 1990 TITLE OF PROJECT (80 characters or less. Title must fit on one line between the borders.) Immunological and Molecular Characterization of Rotavirus Antigens PRINCIPAL INVESTIGATOR (Ust other professional personnel below the Pnncipel Investigator ) (Name, title, laboratory, and institute affiliation) PI: Albert Z. Kapikian, M.D. Others: Mario Gorziglia, Ph.D. Koki Taniguchi, Ph.D. Kazuo Nishikawa, M.D. Kim Green, Ph.D. Yasutaka Hoshino, D.V.M. Head, Epid Section LID, MAID Visiting Associate Visiting Associate Visiting Associate Staff Fellow Visiting Scientist LID, NIAID LID, NIAID LID, NIAID LID, NIAID LID, NIAID COOPERATING UNITS (if any) LAB/BRANCH Laboratory of Infectious Diseases SECTION Epidemiology Section INSTITUTE AND LOCATION NIAID, NTH, Bethesda, MP 20892 TOTAL MAN-YEARS: PROFESSIONAL: CHECK APPROPRIATE BOX(ES) □ (a) Human subjects □ (a1) Minors □ (a2) Interviews D (b) Human tissues E (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed tfn space provided '.) INACTIVE 1989-90 11-62 PHS 6040 (Rev 1/84) CPO 6U-8H PROJECT NUMBER DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT Z01 AI 00478-05 LID PERIOO COVERED October 1, 1989 to September 30, 1990 TITLE OF PROJECT (80 characters or less. Title must fit on one line between the borders ) Development of Rotavirus/Adenovirus Recombinants PRINCIPAL INVESTIGATOR (List other professional personnel below the Pnncipal Invest/gator.) (Name, title, laboratory, and institute affiliation) PI: Jorge Flores, M.D. Visiting Scientist LID, NIAID Others: Gisela Larralde Guest Researcher LID, NIAID Mario Gorziglia, Ph.D. Visiting Scientist LID, NIAID COOPERATING UNITS (if any) LAB/BRANCH Laboratory of Infectious Diseases SECTION Epidemiology Section INSTITUTE AND LOCATION NIAID, NM, Bethesda, MP 20892
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